EPICA-DIPG project
A structured effort connecting therapy, monitoring and delivery
EPICA-DIPG is a European Horizon Europe research project built around an early-phase clinical trial in diffuse intrinsic pontine glioma (DIPG).
A structured effort to evaluate how therapy, monitoring and delivery must work together to generate meaningful evidence in a rare paediatric cancer setting.
Early-phase clinical research
Companion diagnostics
Cross-centre implementation
VISION
Build a connected pathway for future DIPG research
To contribute to a research pathway where new approaches for DIPG can be developed through evidence that connects treatment, monitoring and delivery in a meaningful way.
MISSION
Generate clinical, biological and operational knowledge
To contribute to a research pathway where new approaches for DIPG can be developed through evidence that connects treatment, monitoring and delivery in a meaningful way.
CONNECTED EVALUATION
What EPICA-DIPG is designed to evaluate
Five early-stage questions shape the project’s evidence framework.
01
Safety
Can this treatment approach be delivered safely?
02
Feasibility
Is implementation possible across multiple centres?
03
Biological signals
How can monitoring help interpret what is happening in patients?
04
Monitoring
Testing implementation across participating centres.
05
Delivery conditions
What manufacturing and delivery conditions are required?
EPICA-DIPG does not aim to demonstrate clinical benefit at this stage, but to generate the evidence needed to guide future research.
One research system
Why therapy, monitoring and delivery must be studied together
These elements are interdependent. Studying them together allows the project to generate clinical, operational and translational knowledge.
01
Therapy
Provides the intervention being tested.
02
Monitoring
Enables interpretation of biological response and disease progression.
03
Manufacturing and Delivery
Determine whether the approach can be implemented safely across centres.
Who is it for
Children and adolescents
Families and caregivers
People who require clear, responsible information about research.
Clinical and Research communities
Professionals working in paediatric oncology.
Decision-makers
Regulators, HTA bodies and policymakers who depend on structured evidence.
European Research ecosystem
Collaborative initiatives in paediatric cancer and rare disease research.
Children and adolescents
People with DIPG facing an urgent unmet need.
Families and caregivers
People who require clear, responsible information about research.
Clinical and Research communities
Professionals working in paediatric oncology.
Decision-makers
Regulators, HTA bodies and policymakers who depend on structured evidence.
European Research ecosystem
Collaborative initiatives in paediatric cancer and rare disease research.
Consortium members
Expertise across the research pathway
The consortium combines paediatric clinical centres, research and regulatory expertise, patient organisations, health technology assessment and communication.
